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Long-lasting Changes of Albino Rats Behavior and Brain Bioamines Content After Immunization Against Cholecystokinin-3 and -4

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Abstract

Active immunization against cholecystokinin fragments 31–33 (CCK-3) and 30–33 (CCK-4) results in long-lasting changes of albino rats’ behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.

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Acknowledgment

This work was supported by the Russian Fund of Fundamental Investigations, Grant No. 02–04–4(8083)

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Authors and Affiliations

  1. Department of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, Russia

    Igor Petrovich Ashmarin, Raisa A. Danilova, Maria F. Obukhova & Olga Igorevna Rud’ko

  2. Institute of Molecular Genetics, Moscow, 119922, Russia

    Ludmila A. Andreeva

Authors
  1. Igor Petrovich Ashmarin
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  2. Raisa A. Danilova
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  3. Maria F. Obukhova
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  4. Olga Igorevna Rud’ko
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  5. Ludmila A. Andreeva
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Correspondence to Igor Petrovich Ashmarin.

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Ashmarin, I.P., Danilova, R.A., Obukhova, M.F. et al. Long-lasting Changes of Albino Rats Behavior and Brain Bioamines Content After Immunization Against Cholecystokinin-3 and -4. Neurochem Res 32, 395–399 (2007). https://doi.org/10.1007/s11064-006-9223-7

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  • DOI: https://doi.org/10.1007/s11064-006-9223-7

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